Twice a day: After breakfast and before going to bed.
The latter one goes with mouthwash, and at least once a week some floss. Has worked for me quite well. You might need some more depending on your genes, but it seems to be the golden middle I found for myself (and others who ask me), and even the dentist has yet to tell me to change anything in that routine.
Apart from what has already been said (politics, basic UI) there are a couple more things worth mentioning:
Other than that only personal taste matters in the end, and both federate with eachother, so enjoy it from wherever you are.